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This action may be additive with other agents that can cause hypotension such as antihypertensive agents or other peripheral vasodilators.
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The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy.
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Secondary outcome measures were the use of life support (defined as the use of vasopressor or inotropic therapy, mechanical ventilation, or renal-replacement therapy) at days 5, 14, and 28 after randomization 19; the number of patients with serious adverse reactions while in the ICU (allergic reaction, hemolysis, transfusion-associated acute lung injury, or transfusion-associated circulatory overload) (see the Supplementary Appendix); the number of patients with ischemic events while in the ICU, which included cerebral ischemia (identified from the results of imaging), acute myocardial ischemia (defined by symptoms, electrocardiographic signs, or elevated biomarker levels resulting in an intervention), intestinal ischemia (as observed during endoscopic examination or surgery), or limb ischemia (defined as clinical signs resulting in an intervention) (for full definitions, see the Supplementary Appendix); the percentage of days alive without vasopressor or inotropic therapy, mechanical ventilation, or renal-replacement therapy in the 90 days after randomization; and the percentage of days alive and out of the hospital in the 90 days after randomization.
In 1994, Congress also enacted the Indian Trust Fund Management Reform Act, which recognized the federal government’s preexisting trust responsibilities.